Information-theoretic characterization of the complete genotype-phenotype map of a complex pre-biotic world: Comment on “From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics” by Susanna Manrubia et al.

TitleInformation-theoretic characterization of the complete genotype-phenotype map of a complex pre-biotic world: Comment on “From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics” by Susanna Manrubia et al.
Publication TypeJournal Article
Year of Publication2021
AuthorsG, NC, Adami, C
JournalPhysics of Life Reviews
Volume38
Pagination111-114
ISSN1571-0645
Abstract

How information is encoded in bio-molecular sequences is difficult to quantify since such an analysis usually requires sampling an exponentially large genetic space. Here we show how information theory reveals both robust and compressed encodings in the largest complete genotype-phenotype map (over 5 trillion sequences) obtained to date.

URLhttps://www.sciencedirect.com/science/article/pii/S1571064521000403
DOI10.1016/j.plrev.2021.06.001